When a motor goes bad: A kinesin regulates neuronal survival
Article Abstract:
The kinesin superfamily member KIF4, a microtubule-based molecular motor, regulates the survival of electrically active neurons in the developing brain by modulating the function of poly(ADP-ribose)polymerase-1 in an unexpected way. The function of KIF4, which is expressed in the neonatal and juvenile but not adult brain, is obscure, but a new role is defined for KIF4 as a proapoptotic protein for developing central nervous system neurons.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Agrin gene expression in ciliary ganglion neurons following preganglionic denervation and postganglionic axotomy
Article Abstract:
Agrin production is regulated by post-ganglionic target tissues in the chick ciliary ganglion. This protein is involved in the formation of synapses and the accumulation of the acetycholine receptor at the neuromuscular junction. Preganglionic denervation and postganglionic axotomy of chick ciliary ganglion revealed that only postganglionic axotomy significantly reduced the production of agrin.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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